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Dna Replication

Thursday, November 8, 2012

Technological Landscapes

Technological Landscapes: The Healing Power of Enzyme Replacement Therapy

Lexington-based Shire Human Genetic Therapies (HGT) is a business unit of Shire plc, a global company dedicated to the research, development and commercialization of novel therapies to treat life-threatening genetic diseases.

  It takes a global pharmaceutical company with extensive resources to produce drugs that can alleviate suffering due to unheralded diseases. This is the challenge that Shire plc has chosen for their mission and the Lexington-based Shire’s Human Genetic Therapies (HGT) business unit exemplifies this effort. The business unit focuses on the research, development and marketing of “novel products and services that profoundly enhance the quality of life of patients suffering from rare diseases”. Rare diseases afflict thousands rather than millions of people world-wide. In the United States, medication to alleviate such diseases are often termed orphan drugs and are subject to the Orphan Drug Act of 1983. This Act is designed to encourage …

Monday, July 16, 2012

Technological Landscapes

Technological Landscapes: Accelerated Synthetic DNA Replication for Cancer Research

Lexington-based Raindance Technologies provides innovative microdroplet-based solutions that accelerate research and development for human healthcare and industrial markets.

  That living forms reproduce themselves is a wonder. That we understand the process of cell replication borders on the incredulous. The first level of understanding began in 1870 when the biochemist Friedrich Miescher discovered that, in addition to protein, there was an acid contained within the nucleus of living cells. In early 1900, this nucleic acid was determined to be DNA (deoxyribonucleic acid). This discovery raised the question as to whether-or-not it is the proteins in living cells or the DNA that is the molecule of heredity. It was not until 1944 that DNA was declared the genetic material. In 1952, Maurice Wilkins and Rosalind Franklin used X-ray diffraction to discover that the DNA structure was in the form of a helix. Then on…

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